About the Sunshine Project

Mission of the Sunshine Project

The goal of the Sunshine Project is to identify promising drug combinations to treat and eliminate childhood cancer, through more effective and less toxic treatments. The Sunshine Project is a unique collaborative partnership with over 20 leading pediatric cancer centers across the US. Through these partnerships, top pediatric cancer specialists are able to work together through a network of idea sharing, resulting in the fast-tracking of treatment options into trials. NPCF’s research is affecting treatment protocols nationwide and giving hope to patients and families.

Impact of the Sunshine Project


$25 million dedicated to pediatric cancer research


A coalition of 20+ leading pediatric hospitals nationwide


37 research projects yielding amazing results

History of the Sunshine Project?

In 2005, the National Pediatric Cancer Foundation decided to aggressively pursue a measurable change in the way pediatric cancer research was approached and funded by forming the Sunshine Project.

Through the establishment of the Sunshine Project, the National Pediatric Cancer Foundation has developed a business model unlike any other in the field of pediatric cancer research. Capitalizing on the strengths of researchers from a variety of scientific fields, we have streamlined the process of protocol development in the hopes of delivering more personalized medicine to children with cancer.

Through the Sunshine Project, the National Pediatric Cancer Foundation has launched several clinical trials and many new combinations of drugs and therapies have been, and continue to be, tested. The treatment options being discovered through the Sunshine Project are bringing great promise for children who have not experienced positive results under the standard treatment protocol.

Most Research Ends in the Lab, Ours Makes It To Patients.

Board Reviewed, Vetted, and Governed

The Sunshine Project has established a Clinical Trials Oversight Committee to govern and oversee all research projects. Each trial within the Sunshine Project is board reviewed, vetted, and governed throughout the duration of the trial. Our team has a strong track record of taking promising research ideas and turning them into clinical trials quicker than anyone else. 

Board Reviewed



The Clinical Trials Oversight Committee (CTOC) is a group of pediatric oncologists who specialize in Phase 1 clinical trials. This group of physicians reviews and evaluate the conduct of each trial the National Pediatric Cancer Foundation conducts. Every quarter, the CTOC meets to ensure all clinical research conducted or coordinated by NPCF is scientifically well designed, responsibly managed, appropriately reported, and protects the rights and welfare of human participants.

The CTOC provides an independent review of the interim results of each trial and offers objective guidance regarding unforeseen events that may occur during the course of a study. The CTOC will help to evaluate and ensure events that may have an impact on patient safety are appropriately addressed and managed on an on-going basis.

At the quarterly meetings, discussions will include adverse events, accrual, and protocol deviations. Adverse event and deviation collection begin when a patient is first placed on trial. All events are classified using the NCI Common Toxicity Criteria and are summarized and presented to all members at each safety meeting.