The Clinical Trials Oversight Committee (CTOC) is a group of pediatric oncologists who specialize in phase 1 clinical trials. This group of physicians reviews and evaluate the conduct of each trial the National Pediatric Cancer Foundation conducts. Every quarter, the CTOC meets to ensure all clinical research conducted or coordinated by NPCF is scientifically well designed, responsibly managed, appropriately reported, and protects the rights and welfare of human participants.
The CTOC provides an independent review of the interim results of each trial and offers objective guidance regarding unforeseen events that may occur during the course of a study. The CTOC will help to evaluate and ensure events that may have an impact on patient safety are appropriately addressed and managed on an on-going basis.
At the quarterly meetings, discussions will include adverse events, accrual, and protocol deviations. Adverse event and deviation collection begin when a patient is first placed on trial. All events are classified using the NCI Common Toxicity Criteria and are summarized and presented to all members at each safety meeting.
Oversight Committee Institutions